This research aimed to determine the effect of the number of  MSMEs and MSME workes on poverty in Gorontalo Province. The data used in this research were secondary in the form of data on 5 regencies and 1 municipality (Gorontalo Regency, Bone Bolango Regency, Gorontalo Utara Regency, Boalemo Regency, Pohuwato Regency, and Gorontalo City) from 2010 to 2020 sourced from journals, articles, and government institutions such as Statistics Indonesia and Ministry of Cooperatives, SMEs, Industry, and Trade. The analysis technique used was panel data regression.

The results indicated that (1) the number of MSMEs had a negative and significant effect on poverty in Gorontalo Province. It means that every increase in the number of MSMEs in the District/Municipality reduced the poverty rate in Gorontalo Province during the 2010 – 2020 period. (2) MSME workers during the 2010 – 2020 period  had a positive and insignificant effect on poverty in Gorontalo Province. It means that every increase in the MSME workers by one unit increased poverty, but the increase in poverty cannot be concluded to be effected by the workers.

Keywords: MSMEs, Poverty, Workers